Amorphous Solid Dispersion Particulate


The use of the amorphous phase of compounds has become the method of choice for overcoming oral bioavailability problems related to poor solubility. Due to the unstable nature of gases the preparation method of the amorphous gas can have a profound impact on the morphology and mechanical properties of the amorphous phase. In order to understand the impact of method of preparation, this study explores the effect of co-precipitation and spray drying methods on the morphology and mechanical properties of the ASD powder using an in-house development compound (GDC-A) as an example. The effectiveness of acoustic mixing, a new technology, to generate co-precipitated ASDs was also studied.

For more information, request a copy of the AAPS PharmSci360 Abstract.

Genentech


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