use of the amorphous phase of compounds has become the method of choice for
overcoming oral bioavailability problems related to poor solubility. Due to the
unstable nature of the amorphous material the preparation method can have a
profound impact on the morphology and mechanical properties of the amorphous
phase. In order to understand the impact of method of preparation, this study
explores the effect of co-precipitation and spray drying methods on the morphology
and mechanical properties of the ASD powder using an in-house development
compound (GDC-A) as an example. The effectiveness of acoustic mixing, a new
technology, to generate co-precipitated ASDs was also studied.
For more information, request a copy of the AAPS PharmSci360 poster.