Extended Release Monolithic Microsphere Depot

Characterizing modern drug delivery systems is a challenge due to the decreasing size of delivery vehicles and increasing microstructure complexity. A transport-controlling microporous system often has pore throats as small as a few tens of nanometers—making it difficult to analyze. In this study conducted with OraPharma, a controlled release delivery system with monolithic poly(lactic-co-glycolic acid) (PLGA) microspheres, ranging from 30-80 micrometers, was investigated with FIB-SEM imaging and image-based analytics. The release profile of this controlled release delivery system is predicted through an image-based numerical simulation method

For more information, request a copy of the CRS 2018 Poster.


2D FIB-SEM Cross Section Images

used to quantify porosity, pore morphology, and pore size distributions as well as drug particle size and distribution

ExtendedReleaseImage1 ExtendedReleaseImage2