Characterizing modern drug delivery systems is a challenge due to the decreasing size of delivery vehicles
and increasing microstructure complexity. A transport-controlling microporous
system often has pore throats as small as a few tens of nanometers—making it
difficult to analyze. In this study conducted with OraPharma, a controlled
release delivery system with monolithic poly(lactic-co-glycolic acid) (PLGA) microspheres,
ranging from 30-80 micrometers, was investigated with FIB-SEM imaging and
image-based analytics. The release profile of this controlled release delivery
system is predicted through an image-based numerical simulation method.
For more information, request a copy of the CRS 2018 Poster.