In this joint project with MIT and
Novartis, it was hypothesized that the understanding of a tablet microstructure
is pivotal in bridging our knowledge about the materials, the manufacturing
process, and the tablet properties. A series of MicroCT characterization methods
were developed to untangle material interactions during tablet manufacturing
process leading to an interpretation of tablet compaction mechanisms through
3-D representation of microstructural features.
Numerical simulation of liquid intrusion based on the MicroCT data was
utilized in calculating tablet microstructure permeability introducing a novel
parameter for characterization of tablet dissolution properties.
For more information, request a copy of the Ph.D Thesis