Generic Controlled Release Capsule
Microstructure Equivalence

Microstructures are a critical characteristic to generic drug bio-equivalence. A brand name control release ibuprofen drug was found to have a steady release of API particles through uniform porous networks while the generic drug had irregular release of API through micro-fracture development. We used a FIB-SEM imaging technique to slice open and visualize the cross section of the drug pellets.

FIB-SEM Brand Name vs. Generic Comparison

API in Uniform Porous Network (Left), No Pores for Drug Release (Right)