Formulation Optimization of PLGA Microspheres Prepared Using a Coacervation Method.
With the FDA and UCONN
The patent describing Arestin® (minocycline HCl), a subgingival PLGA microsphere product containing minocycline HCl used to reduce periodontal pocket depth after scaling and root planing, will be off-patent on March 29, 2022 and accordingly, there may be an interest in developing generic equivalents. To achieve PLGA microspheres qualitatively (Q1) and quantitatively (Q2) equivalent to each other, and based on the reference listed drug (RLD), Arestin®, formulation optimization of minocycline chloride microspheres prepared using a coacervation method was investigated. Work is presented by Ruifeng Wang at UConn, please reach out to them to gain access to the poster.
Abstract here.