Changing the World with Microstructure Science
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Press Releases & News
- DigiM Awarded FDA Contract to Study Microstructure Bioequivalence of Polymer-based Long-acting Drugs (in collaboration with the Diane Burgess Laboratory at UConn). Read the press release. Medical News press release available here.
- DigiM’s Quantitative Image Characterization Featured in FDA Workshop. Read the press release and watch the presentation. AZO Materials press release available here.
Upcoming Events
Pharmaceutical
- American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 – Virtual Meeting – October 26-November 5 DigiM will present from 4:00-4:15 pm EST on October 29 about Artificial-Intelligence Image Analysis of API and Microporosity in Drug Products in the Manufacturing and Analytical Characterization Chemical track. Additionally, DigiM will participate in a panel discussion on October 30 from 10:30-11:30 am EST about Artificial Intelligence/Machine Learning: An Emerging Bioanalytical Solution. Lastly, DigiM have the following poster presentations with our collaborators:
- Accelerated Formulation Characterization and Development with AI Image Analysis and Image-Based Release Modeling for PLGA Implant. With Genentech. Link here.
- Drug Particle Characterization Inside Long-Acting Intrauterine Systems with 3D Imaging Analytics. With the FDA and UCONN. Link here.
- Formulation Optimization of PLGA Microspheres Prepared Using a Coacervation Method. With the FDA and UCONN. Link here.
- Particle Analysis within Drug Products: Novel Methods in Quantification using 3D Microscopy. Link here.
- American Institution of Chemical Engineers (AIChE) Annual Meeting – Virtual Meeting – November 16-21. DigiM will host a virtual exhibit booth to connect with pharmaceutical scientists and present two talks:
- Computer Aided Drug Formulation Design with Image-Based Microstructure Modeling on November 18th. Abstract here.
- Linking Process & Performance of Drug Products with Micro-Image Analytics on November 19th. Link here.
- Compaction Simulation Forum (CSF) – Boston, MA – January 2021
Recent Presentations and Publications
- Xi, H., Zhu, A., Klinzing, G.R., Zhou, L., Zhang, S., Gmitter, A.J., Ploeger, K., Sundararajan, P., Mahjour, M., Xi, W. (2020). Characterization of Spray Dried Particles Through Microstructural Imaging. Journal of Pharmaceutical Sciences.August 2020. With Merck. Request paper or manuscript.
- Wu, D., Zhou, L., Zhang, S. (2020). Characterization of Controlled Release Microspheres Using FIB-SEM and Image-Based Release Prediction. AAPS PharmSciTech. July 2020. With Bausch Health. Request paper.
- Zhang, S., Nagapudi, K. (2020). Micro-imaging Based Characterization and Release Prediction of a Long-Acting PLGA Implant. Poster presented at the Long-Acting Injectables and Implantables meeting in La Jolla, CA. With Genentech. Request poster.
- Zhang, S., Goldman, J., Chen, X., Rowe, J., Lin, S., Zhou, L. (2020). Non-Invasive, Quantitative Characterization of Lyophilized Drug Product Using Three-Dimensional X-Ray Microscopy Analytics. Drug Development & Delivery.Read full paper here.
- Howard, J. (2019). Machine-Learning Methods in Image Processing and Analysis of Porous Materials. DigiM whitepaper. Available for request.
- Zhou, L., Stroud, P., Zhu, A., Hinds, J., Blakely, K., Zhang, S. (2019). Characterization of Spray-Dried Aggregates for Tablet Formulation with Microstructure 3D Imaging Analytics. Poster presented at AAPS PharmSci 360 2019 in San Antonio, Texas. With Eli Lilly. Request poster.
- Zhu, L., Yin, D., Qin, Y., Konda, S., Zhang, S., Zhu, A., . . . Lin, H. (2019). Sorption‐Enhanced Mixed Matrix Membranes with Facilitated Hydrogen Transport for Hydrogen Purification and CO2 Capture. Advanced Functional Materials.Read abstract. Request manuscript.
- Howard, J., Lin, S., & Zhang, S. (2019). Uncertainty Quantification in Image Segmentation for Image-Based Rock Physics in a Shaly Sandstone. Petrophysics,60(2), 240-254. Read abstract. Request the manuscript.