DigiM pioneers in 3D microscopic imaging, image analytics, and image-based simulation, with a track-record of joint publications and presentations with our elite customers. Our publications are available for request and download in respective links.

Recent

  1. Zhang, S., Goldman, J., Chen, X., Rowe, J., Lin, S., Zhou, L. (2020). Non-Invasive, Quantitative Characterization of Lyophilized Drug Product Using Three-Dimensional X-Ray Microscopy Analytics. Drug Development & Delivery. Read full paper here.
  2. DigiM Awarded FDA Contract to Study Microstructure Bioquivalence. With UConn. Read the press release. News Medical press release available here.
  3. Zhou, L., Stroud, P., Zhu, A., Hinds, J., Blakely, K., Zhang, S. (2019). Characterization of Spray-Dried Aggregates for Tablet Formulation with Microstructure 3D Imaging Analytics. Poster presented at AAPS PharmSci 360 2019 in San Antonio, Texas. With Eli Lilly. Request poster.
  4. Zhou, L., Chen, X., Goldman, J., Rowe, J., Zhang, S., Lin, S. (2019). Non-invasive Three-dimensional X-Ray Microscopy Imaging Technique for Quantitative Characterization of Lyophilized Drug Product. Poster presented at AAPS PharmSci 360 2019 in San Antonio, Texas. With Bristol-Myers Squibb and Moderna. Request poster.
  5. Zhou, L., Lomeo J., & Zhang, S. (2019). Drug Substance / Drug Product Characterization and Performance Prediction Using High Resolution 3D Micro-Imaging Analysis. Poster presented at Applied Pharmaceutical Analysis 2019 Meeting in Boston, MA and recognized as an Outstanding Poster (September 9-11, 2019). Request a copy of the poster.
  6. Yost, E., Chalus, P., Zhang, S., Peter, S., & Narang, A. S. (2019). Quantitative X-Ray Microcomputed Tomography Assessment of Internal Tablet Defects. Journal of Pharmaceutical Sciences, 108(5), 1818-1830. With Genentech, Lonza, and Roche. Get official copy.
  1. Hao, H., Nagapudi, K., & Zhang, S. (2018). Impact of method of preparation on the morphology and mechanical properties of Amorphous solid dispersion: Comparison of Co-precipitation and Spray Drying. Presented at AAPS PharmSci 360 in Washington DC (November 4-7, 2018). With Genentech. Request a copy of the abstract.
  2. Venters, M., Klaus N., LaChapelle, E., Pluntze, A., Pugh, K., Shaffer, M., & Zhang, S. (2018). Focused Ion Beam Analysis of Lipid Multiparticulates. Presented at AAPS PharmSci 360 in Washington DC (November 4-7, 2018). With Lonza. Request a copy of the abstract.
  3. Zhang, S., Neilly, J., Zhu, A., Chen, J., & Danzer, G. (2018). Quantitative Characterization of Crystallization in Amorphous Solid Dispersion Drug Tablets Using X-Ray Micro-Computed Tomography. Cambridge University Press, 24(S1), 1400-1401. Presented at Microscopy & Microanalysis in Baltimore, MD (August 5-9, 2018). With AbbVie. Download the extended abstract.
  4. Wu, D., & Zhang, S. (2018). Microimaging Characterization and Release Prediction of Controlled Release Microspheres. 18-A-137-CRS. Presented at the Controlled Release Society Annual Meeting and Exposition in New York City, NY (July 22-24, 2018). With OraPharma. Request a copy of the abstract.
  5. Yost, E., Chalus, P., Zhang S., Peter S., & Narang, A.S. (2018). Quantitative X-ray Micro-Computed Tomography Assessment of Internal Tablet Defects. Presented at the Compaction Simulation Forum in San Francisco, CA (June 11-13, 2018). With Genentech. Request a copy of the abstract.
  6. Poozesh, S., Setiawan, N., Arce, F., Sundararajan, P., Rocca, J. D., Rumondor, A., Wei, D., Wenslow, R., Xi, H., Zhang, S., Stellabott, J., Su, Y., Moser, J., Marsac, P. J. (2017). Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles. Powder Technology, 320, 685-695. JPT Web Access.
  7. Zhang, S., and Liu, Z. (2017). Correlative Microimaging and Image-Based Diffusion Simulation to Predict Extended Release Drug Performance. Invited talk at AAPS 2017 Symposium of Assembling an Advanced Analytical Toolkit to Support LAP Dosage Forms in San Diego, CA (November 12-15, 2017). Request a copy of the abstract. Request a copy of the presentation.
  8. Understanding the Process-Product-Performance Interplay of Spray Dried Drug-Polymer Systems through Complete Structural and Chemical Characterization of Single Spray Dried Particles. Poster presented at AAPS 2017, Poster Forum 6: Drug Delivery - Pharmaceutical Technologies - Formulation, in San Diego, CA (November 12-15, 2017). Poster Abstract.
  9. Correlative focused ion beam scanning electron microscope and x-ray micro-computed tomography imaging on multi-scale drug release characterization and 3D-printing manufacturing. Poster Presented at Controlled Release Society 2017 Annual Meeting in Boston, MA (July 16-19, 2017). Poster No. 128. Request a copy of the abstract. Request a copy of the poster.
  10. Advanced Image Characterization and Analysis on Polymer Based Implantable Dosage Formulations. Poster presented at Controlled Release Society 2017 Annual Meeting in Boston, MA (July 16-19, 2017). Poster No. 128. With . Request a copy of the abstract.
  11. Zhang, S., Zhang, C., Brynes, G. (2016). Microscopic Image Based Drug Delivery System Characterization. Presented at AAPS 2016 Annual Conference. (Congratulations to DigiM intern Cheney C.Y. Zhang, who co-authored the abstract based on his summer project in porous material generation using pore-size distribution, a first at McCall Middle School). Request a Copy.
  12. DigiMedicine: FIB-SEM/MicroCT 3D imaging for drug microstructure and deliverability characterization. AAPS National Biotechnology Conference 2016.Request a Copy. Request a Copy of poster.
  13. Advances in Solid State Imaging of Pharmaceutical Systems. Invited talk at AAPS Arden Conference 2016. With Prof. Patrick Marsac, Univ. of Kentucky. Request a Copy.
  14. G. Bryne, J. Chen. (2013). Microstructure Investigation of Controlled Release Multi-Particulates Using FIB-SEM. UKPharmSci 2013. With . Request a Copy.
  15. Microstructural Investigation of Tablet Compaction and Tablet Pharmacological Properties. MIT Ph.D. Thesis 2010. With MIT and Novartis. Request a Copy.

Recent

  1. Howard, J. (2019). Machine-Learning Methods in Image Processing and Analysis of Porous Materials. DigiM whitepaper. Available for request.
  2. Zhang, S., Byrnes, A.P., & Howard, J. (2019). Properties Upscaling in Porosity Systems with Under-resolved Features Using Image-Based Rock Physics. Paper presented at 2019 URTeC Meeting in Denver, CO (July 22-24, 2019). With Whiting. Read abstract. Request presentation. Request paper.
  3. Howard, J., Lin, S., & Zhang, S. (2019). Uncertainty Quantification in Image Segmentation for Image-Based Rock Physics in a Shaly Sandstone. Petrophysics, 60(2), 240-254. Read abstract. Request paper.
  4. Howard, J., Lin, S., & Zhang, S. (2018). Uncertainty Quantification in Image Segmentation for Image-based Rock Physics in a Shaly-sandstone. Proceedings of International Symposium of the Society of Core Analysts, Trondheim, Norway, 27-30 August 2018. Request paper.
  5. Byrnes, A.P, Zhang, S., Canter, L., Sonnenfeld, M.D. (2018). Application of Integrated Core and Multiscale 3-D Image Rock Physics to Characterize Porosity, Permeability, Capillary Pressure, and Two and Three-Phase Relative Permeability in the Codell Sandstone, Denver Basin, Colorado. Unconventional Resources Technology Conference, URTeC 2901840, Houston, TX (July 23-25, 2018). With . Request a copy of the manuscript.
  1. Zhang, S. & Ionkina, N. (2018). The Impact of Capillary Condensation on the Hydrocarbon Storage and Mobility. 2018 AAPG Annual Convention & Exhibition, P102, 2856053, Salt Lake City, UT (May 20-23, 2018).Request a copy of the extended abstract. Request a copy of the poster.
  2. Zhang, S., Canter, L., Sonnenfeld, M. (2017). Capillary Fluid Dynamics within Unconventional Rocks Investigated by Scanning Electron Microscope. AAPG Bulletin, November 2017. With . AAPG Website Access. Request a copy of preprint.
  3. DigiM is highlighted in Journal of Petroleum Technology June 2nd 2017 article "Need a Faster Measure of Relative Permeability? Take a CT Scan and Follow With Digital Rock Analysis", by Stephen Rassenfoss, JPT Emerging Technology Senior Editor.
  4. Byrnes, A.P, Zhang, S., Canter, L., Sonnenfeld, M.D. (2017). Two-phase and three-phase relative permeability of unconventional Niobrara chalk using integrated core and 3D image rock physics. Joint symposium by Rocky Mountain Association of Geologists and Denver Well Logging Society, Geology and Petrophysics of Unconventional Mudrocks, in Golden, CO (September 27-28, 2017). With Whiting. Abstract download.
  5. Application of integrated core and 3D image rock physics to characterize Niobrara chalk porosity, permeability, capillary pressure, and two and three-phase relative permeability. Accepted to present and publish by URTec 2017. With . Request a copy of full paper. Request the presentation.
  6. Canter, L., Zhang, S., Sonnenfeld, M., Bugge, C., Guisinger, M., & Jones, K. (2016). Primary and Secondary Organic Matter Habit in Unconventional Reservoirs. AAPG Memoir 102: Imaging Unconventional Reservoir Pore Systems. Terri Olson, editor. With . Request a Copy.
  7. Jin, X., Wang, X., Sun, L., Li, J., Liu, X., Yao, Z., . . . Zhang, S. (2016). Study of Petrophysical Properties Using Nano-Scale Resolution Electron Microscopy and 3D to 2D Upscaling. Journal of Nanoscience and Nanotechnology, 16(9), 9690-9698. With . Request a Copy.
  8. Petrographic Features of Kerogen in Unconventional Shales and Their Effect on Hydrocarbon Petrophysics. Abu Dhabi International Petroleum Exhibition & Conference held in Abu Dhabi, UAE (November 11–14,2012). SPE162612. With . Request a Copy.
  9. Upscaling of Heterogeneous Rock Properties via a Multiscale Image to Simulation Approach. Comsol Conference 2012, Boston, MA (October 3-5, 2012). With .
  10. Micron to millimeter upscale of shale rock properties based on 3D imaging and modeling. Society of Core Analysis 2012 Meeting, paper A20, Aberdeen, UK (August 26-31, 2012). With . Request a Copy.
  11. Capillary Condensation and NMR Relaxation Time in Unconventional Shale Hydrocarbon Resources. SPWLA 53rd Annual Logging Symposium (June 16-20, 2012). With . Request a Copy.
  12. Measurements of Porosity and permeability analysis on nanoscale FIB-SEM tomography of shale rock. ExxonMobil 2012 Unconventional Summit, Houston, USA (February 25-27, 2012). With and IOL Calgary.
  13. Porosity types and sizes in Shales, Measurements of Porosity and permeability analysis on nanoscale FIB-SEM tomography of mudstones. ExxonMobil 2012 Summit, Houston, TX (February 25-27, 2012). With .
  14. Poromechanics Investigation at Pore-scale Using Digital Rock Physics Laboratory. Multiphysics I Session, Comsol Conference 2011 Proceedings, Boston, MA (October 13-15, 2011). With .
  15. Porosity and permeability analysis on nanoscale FIB-SEM tomography of shale rock. Society of Core Analysis 2011 Meeting, paper A30, Austin, TX (September 18-21, 2011). With . Request a Copy.
  16. Poromechanics from Volume Averaging: Lining pore-scale physics to macro-scale. Society of Exploration Geophysicists 2011 Annual Meeting. W-4: From Image to Insight: How Can We Leverage Pore-Scale Observations Through Rock Physics Models. San Antonio,TX (September 18-23, 2011). With.
  17. A virtual material studio to study rock petrophysical properties. The 11th International Conference on  Magnetic Resonance Microscopy (ICMRM)/Joint Topic Conference on NMR in Well Logging and Core Analysis, Beijing, China (August 14-18, 2011). 2011-08 ICMRM; MRI Digital Rock Physics. With University of Alberta.
  18. The Analysis and Simulation of Rock Properties Using FIB-SEM and Virtual Material Studio. NAFEMS World Congress 2011, Boston, MA (May 22-26, 2011). With  . Request a Copy.
  19. Analysis and Simulation of Rock Properties. Edward Brown (Editor). Comsol News 2011, p 58-59, May 2011. Interview.

Recent

  1. Tracey, J., Lin, S., Jankovic, J., Zhu, A., Zhang, S. (2019). Iterative Machine Learning Method for Pore-Back Artifact Mitigation in High Porosity Membrane FIB-SEM Image Segmentation. Microscopy and Microanalysis. Download here.
  2. Zhu, L., Yin, D., Qin, Y., Konda, S., Zhang, S., Zhu, A., . . . Lin, H. (2019). Sorption‐Enhanced Mixed Matrix Membranes with Facilitated Hydrogen Transport for Hydrogen Purification and CO 2 Capture. Advanced Functional Materials. Read abstract. Request manuscript.
  3. Jankovic, J., Zhang, S., Putz, A., Saha, M. S., & Susac, D. (2019). Multiscale imaging and transport modeling for fuel cell electrodes. Journal of Materials Research, 34(4), 579-591. Read abstract. Request paper.
  4. Kamp, J., Zhang, S. (2017) High Resolution X-ray Computed Tomography for the Measurement and Simulation of Decreased Permeability in the Wall-Flow Diesel Particulate Filter due to the Accumulation of Lubricant-Derived Ash. 2017 MRS Fall Meeting (November 27, 2017). With MIT.
  1. Putz, A. M.V., Zhang, S., Jankovic, J., Susac, D., Chen, J. (2017). Multi-Scale Image-Based Characterization of Electrochemical Energy Material System. 2017 MRS Fall Meeting (November 30, 2017). With AFCC.
  2. Putz, A. M.V., Zhang, S., Jankovic, J., Susac, D., Chen, J. (2017). Microscopy Supported Multi-Scale Modeling of PEM Fuel Cells. 231st Electrochemical Society (ECS) Meeting in New Orleans, LA (May 28-June 1, 2017). With AFCC.
  3. Kamp, C. J., Zhang, S., Bagi, S., Wong, V., Monahan, G., Sappok, A., & Wang, Y. (2017). Ash Permeability Determination in the Diesel Particulate Filter from Ultra-High Resolution 3D X-Ray Imaging and Image-Based Direct Numerical Simulations. SAE International J. Fuels Lubr, 10(2), 608-618. With MIT and Cummins. Read abstract.
  4. Marsh, M., Zhang S., Itty, P., Monitero, P. (2013). Microstructural Evolution in Concrete by In-Situ X-Ray Microtomography. 2013 International Cement Microscopy Association 2013 Conference in Chicago, IL (May 1, 2013).

Recent

  1. Tracey, J., Lin, S., Jankovic, J., Zhu, A., Zhang, S. (2019). Iterative Machine Learning Method for Pore-Back Artifact Mitigation in High Porosity Membrane FIB-SEM Image Segmentation. Microscopy and Microanalysis. Download here.
  2. Zhang, S., Byrnes, A. P., Jankovic, J., & Neilly, J. (2019). Management, Analysis, and Simulation of Micrographs with Cloud Computing. Microscopy Today, 27(2), 26-33. Read here.
  3. Cheney C.Y. Zhang. Reconstruction of Three-Dimensional Micro-Structures From Two-Dimensional Microscopic Images Using Texture Synthesis and Phase Field Method. Poster ID PDP-54. Request a copy of the extended abstract.
  4. DigiM Artificial Intelligence Image Processing. DigiM Technology Highlight 2017 July Issue. July 29, 2017. Request a Copy.
  1. DigiM FIB-SEM Curtaining Removal. DigiM Technology Highlight. February 25, 2015. Request a Copy.
  2. Zhang, S. (2014). Integrated Material Characterization and Property Prediction Using 3D Image-based Analytics and Modeling. Presented at TMS 2014 Annual Meeting in San Diego, CA (February 16-20, 2014).
  3. Seminar. From 3D Microtomography to Qualitative and Quantitative Analysis. June 27-28, 2013. With Zeiss Xradia.
  4. 3D Correlative Microscopy: Analysis and Modeling Challenges. Presented at 2013 Yale Microscopy Workshop, Yale University, New Haven, CT (June 4, 2013).
  5. G. Tallec, P. Westenberger, N. Combaret, S. Zhang, & D. Lichau (2013). New approaches for characterization of porous media: from segmented 3D FIB/SEM images to material properties simulation.5th International Conference on Porous Media & Annual Meeting, Prague, Czech Republic, (May 21-24, 2013).
  6. Advanced processing and modeling methods for porous material FIB-SEM data. Presented at 6th Annual FIB SEM Workshop at Harvard University, Cambridge, MA (March 1, 2013).
  7. On quantification of fibrous material. TMS 2013 Annual Meeting, San Antonio, TX (March 3-7, 2013).
  8. The analysis and modeling of CT scan data at multiple scales in food, metrology and energy applications. CT Scan Workshop Development on non-medical environment State of the Art. INRS-ETE. Quebec City (March 6-9, 2012).
  9. Modeling and simulation based on 3D micro to nano-scale imaging. Presented at FIB SEM User Group Meeting. Carnegie Institution of Washington, Washington DC (February 24, 2012).
  10. 3D Visualization and Analysis for Material and Life Sciences. Presented at University of Delaware Visualization Seminar (February 23, 2012).
  11. Preparation and Characterization of an Insensitive RDX-based Nanocomposite Explosive. Symposium Y: Advances in Energetic Materials Research. 2011 Material Research Society (MRS) Fall Meeting & Exhibit in Boston, MA (November 26-30, 2011). With Stevens Institute of Technology and US Army Research.
  12. From 3D images to simulations -- practical issues and software tools. International Conference on Flows and Mechanics in Natural Porous Media from Pore to Field Scale - Pore2Field in Rueil-Malmaison, France (November 16-18, 2011).
  13. 3D Data Analysis Workshop. Presented at The 11th International Conference on Magnetic Resonance Microscopy (ICMRM)/Joint Topic Conference on NMR in Well Logging and Core Analysis in Beijing, China (August 14-18, 2011).
  14. 3D visualization and quantification on Confocal microscopic and FIB/SEM data. Presented at Stevens Institute of Technology (June 23, 2010).
  15. Advanced 3D visualization and Analysis on FIB data. Presented at DC Area FIB User Group Meeting in Gaithersburg, MD (February 25, 2010).
  16. 3D Data Acquisition and Processing. NIST Workshop on FIB/SEM Nanotomography in Gaithersburg, MD (February 4-5, 2010).
  17. Invited Seminar. 3D Microscopy Data: from image space to pore space, from qualitative visualization to quantitative analysis. Second mini-workshop on 3D imaging in microscopy, National Institute for Nanotechnology in Edmonton, Alberta, Canada, (October 14-15, 2010).
  18. Visualization Challenges in CAE. Presented at NAFEMS Webinar Series 2010 (July 28, 2010). NAFEMS Viz-webinar (Panelist).
  19. Recent Improvements in Display and Analysis of NDE Data at NASA. QNDE 2010, San Diego, CA (July 18-23, 2010). With . Request a Copy.
  20. Visualization and Analysis Solutions for Material Sciences along with RoboMet.3D. Presented at MRSEC Summer School 2010 on “Methods for 3D Microstructural Studies”, Carnegie Mellon University.
  21. Drying of Corn Kernels: From Experimental Images to Multi-scale Multi-physics Modeling. Comsol Conference Proceeding in Boston, MA (October 8-10, 2009). With University of Illinois at Urbana-Champaign.
  22. Advanced 3D Data Analysis and Visualization in Aluminum Die Casting using Computed Tomography. Presented at the Proceeding of Materials Science & Technology Conference 2009 in Pittsburgh, PA (October 2009). With North Star Imaging. Request a Copy.
  23. 3D Material Characterization. Presented at Material Research Society (MRS) 2008 Fall Conference & Exhibition in Boston, MA (December 2-4, 2008).

Recent

  1. Wei, D., Jacobs, S., Modla, S., Zhang, S., Young, C. L., Cirino, R., Caplan, J., Czymmek, K. (2012). High-resolution three-dimensional reconstruction of a whole yeast cell using focused-ion beam scanning electron microscopy. BioTechniques, 53(1), 41-48. Cover page story and editor highlight. Read here.